Rat liver microsomal progesterone metabolism: Evidence for differential Troleandomycin and pregnenolone 16α-carbonitrile inductive effects in the cytochrome P -450 III family
Identifieur interne : 004A25 ( Main/Exploration ); précédent : 004A24; suivant : 004A26Rat liver microsomal progesterone metabolism: Evidence for differential Troleandomycin and pregnenolone 16α-carbonitrile inductive effects in the cytochrome P -450 III family
Auteurs : Christian Larroque [France] ; Reinhard Lange [France] ; Patrick Maurel [France] ; Réjean Langlois [Canada] ; Johan E. Van Lier [Canada]Source :
- [ 0022-4731 ]
Abstract
The effect of Troleandomycin (TAO)† and pregnenolone 16α-carbonitrile (PCN) on the hepatic microsomal progesterone metabolism in the rat is evaluated. Over thirteen hydroxylated progesterone derivatives are detected, including the novel 6β,21-, 6β,16α-, 6β,16β- and 2,21-dihydroxy derivatives, suggesting the induction of several cytochrome P-450 isozymes. PCN treatment results overall in an augmented production of progesterone metabolites whereas TAO treatment both induces and represses specific hydroxylase activities. Progesterone metabolism with purified isozymes isolated from liver microsomes from TAO and PCN treated rats differs significantly from that observed with intact microsomes, reflecting the complexicity of the induction pattern of the cytochrome P-450 III family.
Url:
DOI: 10.1016/0022-4731(89)90305-1
Affiliations:
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Van Lier</name><affiliation wicri:level="1"><country>Canada</country><wicri:regionArea>The Medical Research Council Group in the Radiation Sciences, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><idno type="ISSN">0022-4731</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-4731</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of Troleandomycin (TAO)† and pregnenolone 16α-carbonitrile (PCN) on the hepatic microsomal progesterone metabolism in the rat is evaluated. Over thirteen hydroxylated progesterone derivatives are detected, including the novel 6β,21-, 6β,16α-, 6β,16β- and 2,21-dihydroxy derivatives, suggesting the induction of several cytochrome P-450 isozymes. PCN treatment results overall in an augmented production of progesterone metabolites whereas TAO treatment both induces and represses specific hydroxylase activities. Progesterone metabolism with purified isozymes isolated from liver microsomes from TAO and PCN treated rats differs significantly from that observed with intact microsomes, reflecting the complexicity of the induction pattern of the cytochrome P-450 III family.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Larroque, Christian" sort="Larroque, Christian" uniqKey="Larroque C" first="Christian" last="Larroque">Christian Larroque</name></region><name sortKey="Lange, Reinhard" sort="Lange, Reinhard" uniqKey="Lange R" first="Reinhard" last="Lange">Reinhard Lange</name><name sortKey="Maurel, Patrick" sort="Maurel, Patrick" uniqKey="Maurel P" first="Patrick" last="Maurel">Patrick Maurel</name></country><country name="Canada"><noRegion><name sortKey="Langlois, Rejean" sort="Langlois, Rejean" uniqKey="Langlois R" first="Réjean" last="Langlois">Réjean Langlois</name></noRegion><name sortKey="Van Lier, Johan E" sort="Van Lier, Johan E" uniqKey="Van Lier J" first="Johan E." last="Van Lier">Johan E. 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